Table 1

Fanconi gene mutations in pancreatic cancera

Gene and settingMutationsLOHbOriginAge (yrs)
BRCA2 (familial) (reference population)17%Inherited66.0
66.7
BRCA2 (sporadic) (reference population)7–10%LOHUsually inherited71.5
64.3
FANCC (sporadic)
 PX19 tumorD195V (GAT to GTT)LOHInherited44
 PX102 tumorFrameshift (CCTTAAA to CA)LOHSomatic47
 CAPAN2 cell lineE521K (GAG to AAG)cNo LOHUnknown56
FANCG (sporadic)
 Hs766T cell lineE105ter (GAG to TAG)LOHProbably inherited46
  • a BRCA2 data are from Refs. 4 5 6 . Average ages for BRCA2 mutations include only inherited mutations. PX19 and PX102 had no family history of cancer by chart review. Variants present in the constitutional DNA were considered inherited.

  • b LOH in tumors resulting in homozygosity for the mutation.

  • c Functional significance unknown. −, not studied.