Table 2

Number of topotecan-responsive genes detected as a function of drug concentration, time of exposure, and p53 status

TreatmentHCT-116 (p53+/+)HCT-116 (p53−/−)
InducedRepressedInducedRepressed
LD, 1.5 h13002
LD, 3 h224a416a1111a14
LD, 6 h121301
HD, 3 h48178a142483a16203949a
HD, 6 h154387415
Any treatment186a487a3153
  • a Summary numbers are not simple sums because the same gene sometimes responds at different times and doses.