Table 2

Tumor development by parental UACC 903 melanoma cells and chromosome 10 hybrid cell lines

Cell line (number of sites injected)Tumor size (mean ± SE in mm3)
Day 7Day 14Day 21Day 28
Parental cell line
UACC 903 (>20)143 ± 19725 ± 832587 ± 176a
Hybrids cell lines expressing PTEN
29A (8)5 ± 223 ± 521 ± 497 ± 10
36A (6)0b000
36B (20)36 ± 525 ± 519 ± 416 ± 3
37A (8)0000
37B (8)0000
Revertant cell lines lacking PTEN
36A-R1 (8)33 ± 10176 ± 27746 ± 562014 ± 194
36A-R2 (8)83 ± 8331 ± 26969 ± 742665 ± 86
  • a Not available since mice were euthanized at day 21.

  • b 0, no measurable tumor could be detected.