Table 1

Intratibial tumor growth in nude mice

Study groupaIncidenceb (n)Tumor weight (mg)Bone lysisaBody weight (g)
Median (range)Median (range)
Control12/14104 (45–356)3.031 (27–40)
Taxol8/1015d (0–85)2.730 (25–36)
PKI 1665/721d (0–56)1.3e29 (24–32)
PKI 166 + Taxol5/101d (0–41)0.9f28 (25–34)
  • a RBM1-IT4 human RCC cells (4 × 105) were injected into the tibia of nude mice. Three days later, groups of mice were treated with i.p. injections of Taxol (200 μg) alone (once a week), oral feedings of PKI 166 (100 mg/kg) alone (three times a week), Taxol in combination with PKI 166, or saline (control). All mice were killed on day 66.

  • b Number of positive mice by H&E staining/number of mice injected.

  • c The mean score on a numeric scale of 0–4.

  • d Compared with controls: P < 0.05.

  • e P < 0.01 compared with controls.

  • f P < 0.001 compared with controls.