Table 1

Analysis of EXO1 variants in CRC probands and controls

Results of the Finnish, Dutch/Norwegian, United Kingdom, Danish, and combined data sets. The last column lists the 9 candidate EXO1 mutations reported previously (13) .

ExonNucleotide changeProtein changeFinnish CRC probandsFinnish controlsDutch/Norwegian CRC probandsDutch controlsUnited Kingdom CRC probandsUnited Kingdom controlsDanish CRC probandsDanish controlsCombined CRC probandsCombined controlsWu et al. (13) CRC probands
2T to CVal27Ala–/109–/112–/155–/92–/264–/2041/258
4G to AGlu109Lys–/18–/20–/155–/92–/173–/1122/258
5G to TAla137Ser–/18–/201/142–/711/160–/91
9T to GLeu410Arg–/109–/1121/154–/1141/263–/2262/258
10T to GPhe438Cys–/18–/201/154–/1041/172–/124
11A to GSer610Gly1/300–/3731/155–/522/4181/2081/97–/955/9701/7283/258
11C to TPro640Ser3/3003/3733/150–/525/4182/2081/972/9512/9657/7281/258
11C to GPro640Ala1/3001/3731/1501/523/4182/2082/97–/957/9654/7301/258
11C to TAsp661Asp–/18–/202/150–/522/168–/72
13IVS12-1G to C–/83–/5041/1493/2001/2323/7041/258
13IVS12-1G to A–/831/504–/149–/200–/2321/704
13G to AGly759Glu3/10911/1121/1491/2004/25812/3122/258
13C to TPro770Leu–/109–/112–/149–/200–/258–/3121/258
14C to TAla827Val–/18–/20–/891/901/1071/110