Table 1

Average levels of integrin subunit expression on cells of LN5-secreting or nonsecreting human pancreatic carcinoma cell lines

(A) LN5-secreting cellsa (n = 6) Average (± SD)(B) LN5-non-secreting cellsb (n = 5) Average (± SD)Expression ratiocPd
α11.65 (± 0.54)1.18 (± 0.38)1.4NS
α238.6 (±29.2 )38.9 (±23.7 )0.99NS
α350.1 (±35.1 )34.8 (±20.7 )1.44NS
α51.67 (± 0.53)7.26 (± 3.26)0.23<0.002
α627.5 (±15.8 )12.4 (±14.6 )2.22NS
αv12.8 (± 6.52)14.9 (±10.7 )0.86NS
β180.4 (±33.2 )74 (±40.2 )1.09NS
β32.62 (± 1.28)5 (± 1.68)0.52NS
β419 (± 9.67)2.32 (± 1.31)8.19<0.002
  • a Relative fluorescence intensity of integrin subunits on cells of each of the 6 human pancreatic tumor cell lines (including KP-2, KP-3, AsPC-1, HPAC, BxPC-3, and SUIT-2) was obtained from the flow cytometric analysis. The average levels were obtained by averaging these data from the 6 cell lines.

  • b Relative fluorescence intensity of integrin subunits on cells of each of the 5 human pancreatic tumor cell lines (including MIApaca-II, PANC-1, KP-1, KP-4, and PSN-1) was obtained from the flowcytometric analysis. The average levels were obtained by averaging these data from the 5 cell lines.

  • c The significance of integrin subunit expression on cells of the pancreatic cell lines secreting LN5 is represented by the expression index, shown as the average level on cells of the LN5-secreting cell lines (A) corrected for that on the nonsecreting cell lines (B).

  • d Statistically significant differences between (A) and (B) were analyzed by the test for equal variance. NS, not significant.