Genotype analysis of the pro/leu polymorphism at codon 198 of the human GPx-1 gene obtained from breast cancer samples and cancer-free individuals
DNAs from individuals were genotyped at codon 198 of the GPx-1 gene as described in the text from either tumor samples or lymphocytes from cancer-free individuals and are presented in the table. Statistical significance for the difference in allele distribution was P < 0.05. The OR of the Leu/Leu subgroup is 1.906 compared to the Pro/Pro subgroup (P = 0.045).
| GPx-1 (codon 198) | Cancer-free (n = 517) | Breast cancer (n = 79) | OR (95% confidence limits) |
|---|---|---|---|
| Pro/Pro | 244 (47.2%) | 36 (45.6%) | 1.00 |
| Pro/Leu | 209 (40.4%) | 25 (31.6%) | 0.81 (0.471–1.395) |
| Leu/Leu | 64 (12.4%) | 18 (22.7%) | 1.906 (1.016–3.576) |