Table 1

BRAF mutation frequencies in different stages of melanoma progression

SampleBRAF mutation frequencyNRAS mutations in BRAF wild-type lesionsCombined mutation frequency
Melanocytic nevi (benign)17/240/771%
RGP (early melanoma)2/200/1810%
VGP (invasive melanoma)5/81/375%
Metastatic melanoma8/131/569%
Melanoma cell lines18/253/784%