Table 1

Characteristics of BRAF and N-RAS mutations in melanoma tissues and cell lines

A. Metastatic sitenTotal mutant (%)Mutation data
nBRAFN-RAS
Lymph node2814 (50)14V599EWT
Soft tissue228 (36)7V599EWT
1WTQ61R
Lung115 (45)3V599EWT
1V599RWT
1V599KWT
Visceral (except lung)169 (56)7V599EWT
1aG468RY64N
1WTQ61L
Total metastases7736 (47)
Paired normal tissuesb360 (0)
B.Cell lineBRAFN-RAS
19V599EWT
29V599EWT
85G468SWT
94V599EWT
100V599EWT
103WTQ61R
147WTQ61R
173WTWT
187WTWT
192V599EWT
197WTWT
  • a Both mutations in the same case.

  • b Normal tissue from patients whose tumors contained BRAF or N-RAS mutations.