Mutation spectrum of gpt gene from livers of gpt/Ogg1+/− and gpt/Ogg1−/− mice which had undergone partial hepatectomy after treatment with KBrO3 for 12 weeks
The number of colonies with independent mutations are shown. The number of total colonies are in parenthesis.
| Control | KBrO3 | |||||||
|---|---|---|---|---|---|---|---|---|
| Ogg1 | Ogg1 | Ogg1 | Ogg1 | |||||
| Before | After | Before | After | Before | After | Before | After | |
| Base substitution | ||||||||
| Transversions | ||||||||
| GC→TA | 5 | 4 | 8 | 8 | 7 | 3 | 11 | 31 (38) |
| GC→CG | 1 | 2 | 2 | 0 | 2 | 0 | 2 (3) | 1 |
| AT→TA | 1 | 0 | 0 | 1 | 2 | 2 | 2 | 0 |
| AT→CG | 2 (3) | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| Transitions | ||||||||
| GC→AT | 4 | 2 | 3 | 3 | 4 | 3 (18) | 3 | 2 |
| AT→GC | 0 | 1 | 0 | 0 | 1 (7) | 1 | 1 | 0 |
| Deletion | ||||||||
| Single bp | 0 | 1 | 0 | 1 | 3 | 2 | 0 | 2 |
| ≥2 bp | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
| Insertion | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 |
| Complex | 1 (3) | 2 (3) | 1 | 0 | 0 | 2 | 1 | 2 |
| Total | 14 (17) | 12 (13) | 16 | 14 | 21 (27) | 14 (29) | 20 (21) | 38 (45) |