Table 2

Mutation spectrum of gpt gene from livers of gpt/Ogg1+/− and gpt/Ogg1−/− mice which had undergone partial hepatectomy after treatment with KBrO3 for 12 weeks

The number of colonies with independent mutations are shown. The number of total colonies are in parenthesis.

ControlKBrO3
Ogg1Ogg1Ogg1Ogg1
BeforeAfterBeforeAfterBeforeAfterBeforeAfter
Base substitution
 Transversions
  GC→TA5488731131 (38)
  GC→CG1220202 (3)1
  AT→TA10012220
  AT→CG2 (3)0011000
 Transitions
  GC→AT423343 (18)32
  AT→GC01001 (7)110
Deletion
 Single bp01013202
 ≥2 bp00001100
Insertion00200000
Complex1 (3)2 (3)100212
Total14 (17)12 (13)161421 (27)14 (29)20 (21)38 (45)