Table 1

Association between PGR polymorphism and breast cancer risk

PR genotypeaCases, n (%)Controls, n (%)OROR
GG864 (87)1218 (90)1.0b1.0c
AG + AA126 (13)139 (10)1.26 (0.97–1.63)1.33 (1.01–1.74)
Premenopausal women
GG93 (91)98 (89)1.0d1.0e
AG + AA9 (9)12 (11)0.8 (0.32–2.00)0.76 (0.28–2.00)
Postmenopausal women
GG711 (87)1047 (90)1.0f1.0g
AG + AA109 (13)120 (10)1.34 (1.02–1.77)1.41 (1.06–1.87)
  • a Numbers may vary because of missing genotypes.

  • b Conditional logistic regression adjusted for the matching variables: age, menopausal status, postmenopausal hormone use at blood draw, date at blood draw, time at blood draw, and fasting status.

  • c Conditional logistic regression adjusted for matching variables and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.

  • d Unconditional logistic regression adjusted for matching variables: age, date at blood draw, time at blood draw, and fasting status.

  • e Unconditional logistic regression adjusted for matching variables in d and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, and first-degree family history of breast cancer.

  • f Unconditional logistic regression adjusted for matching variables in b.

  • g Unconditional logistic regression adjusted for matching variables in b and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, first-degree family history of breast cancer, and duration of postmenopausal hormone use.