Table 2

PR polymorphisms and BMI for postmenopausal women only: frequencies and ORs for breast cancer risk

GenotypeBMI <25 kg/m2, n (%)25 ≤ BMI < 30 kg/m2, n (%)BMI ≥30 kg/m2, n (%)
CasesControlsOR (95% CI)CasesControlsOR (95% CI)CasesControlsOR (95% CI)
+331 GGa400 (88)536 (88)1.0210 (85)344 (91)1.00 (0.76–1.31)101 (85)167 (91)1.19 (0.75–1.90)
+331 AG + AA55 (12)72 (11)1.06 (0.72–1.56)36 (14)32 (9)1.98 (1.16–3.39)18 (15)16 (9)2.30 (1.02–5.21)
  • Unconditional logistic regression adjusted for matching variables and age at menarche, parity, age at first birth, BMI at age 18, weight gain since age 18, benign breast disease, and first-degree family history of breast cancer. ORs are independent risks for breast cancer following joint variables: +331 GG and 25 ≤ BMI ≤ 30, +331 GG and BMI >30, +331 AG + AA and BMI <25, +331 AG + AA and 25 ≤ BMI ≤ 30, +331 AG + AA and BMI>30, compared to +331 GG and BMI <25 (reference group). Likelihood ratio test for interaction of BMI and +331 is 0.10; Wald test result is 0.11.

  • a Reference category.