Table 1

Baseline characteristics of the 84 patients with apparently sporadic phaeochromocytomas

Extra-adrenal tumors corresponding to phaeochromocytomas of the organ of Zuckerkandl (five patients) and of the urinary bladder (one patient).

ParameterAdrenal tumorExtra-adrenal tumorWith metastases at first interventionRecurrence or metastases at follow-upP
Number576714
Age at first intervention, years45.1 ± 13.543.3 ± 14.344.3 ± 13.539.4 ± 12.50.57
Sex (M/F)24/332/44/36/80.84
Symptom duration, years2.1 ± 3.35.5 ± 9.12.1 ± 1.51.6 ± 1.50.16
Hypertension duration, years4.4 ± 6.77.1 ± 7.21.3 ± 1.25.8 ± 10.30.45
Body mass index, kg/m224.3 ± 5.523.1 ± 2.620.7 ± 3.221.3 ± 3.90.24
Tumor diameter49.7 ± 21.852.5 ± 10.892.5 ± 36.790.4 ± 41.1<0.0001
Tumor weight63 ± 9492 ± 90358.7 ± 220.9354.1 ± 402.3<0.0001
Urinary metanephrines, μmol/day33 ± 3231 ± 1651 ± 2876 ± 480.003
A/A+ NA (%)a12.8 ± 15.60.7 ± 1.01.0 ± 1.58.0 ± 7.40.10
Mean follow-up, months91 ± 5165 ± 42114 ± 75175 ± 91<0.0001
Number followed up574714
Germ-line mutations/polymorphisms
 RET0000
 VHL2000
 SDHDb3201c
 SDHB1223
  • a A, adrenaline; NA, noradrenaline.

  • b Mutations detected correspond to the G12S and H50R polymorphisms.

  • c Patient also had a SDHB mutation.