Table 5

Respiratory chain enzyme activity in phaeochromocytomas with or without SDHB mutationsa

ID #SDHB germ-line mutations1p LOHSuccinate cytochrome c reductase (CII + CIII)Quinol cytochrome c reductase (CIII)QCCR/SCCR
(nmol/min/mg protein)
P106A43P+<0.5142>280
P107725 del c+139.539.5
P109R230C+<0.5277>500
P117754, 755 del tg+<162.5>62.5
P183R46Q+<0.01320>320
P188R46Q+<1112.5>112.5
P195R46G+1.5160107
SDHB mutation-positive tumors (n = 7)+<0.8 ± 0.5159 ± 05>203 ± 169
SDHB mutation-negative tumors (n = 6)75 ± 30189 ± 702.7 ± 0.6
  • a No SDHB or SDHD mutation was detected in control phaeochromocytoma group (SDHB mutation-negative tumors).