Table 1

Comparison of inhibitor potencies and specificities against the PIKK family enzymesa

EnzymeNU7026 IC50m)Wortmannin IC50m)
DNA-PK0.23 ± 0.010.26 ± 0.02
PI 3-K13.0 ± 3.00 0.003 ± 0.00
ATM>1000.30 ± 0.05
ATR>1004.4 ± 0.18
  • a Each IC50 value is computed from the mean of more than or equal to three independent experiments ± SE.