Table 3

Cellular potencies of SK inhibitors

Varying concentrations of the indicated SK inhibitors were evaluated for inhibition of proliferation of the indicated cell lines. Data represent the concentrations required to inhibit cell proliferation by 50% and are the mean ± SD of triplicate experiments.

CompoundCytotoxicity toward
T24aMCF-7aNCI/ADRaMCF-7/VPa
I1.1 ± 1.20.4 ± 2.30.8 ± 1.32.9 ± 2.0
II4.6 ± 1.61.2 ± 1.31.3 ± 1.10.9 ± 1.8
III5.8 ± 1.56.8 ± 1.56.2 ± 1.524.6 ± 1.9
IV7.8 ± 2.01.0 ± 1.71.2 ± 2.41.8 ± 1.1
  • a IC50m).