Table 1

Data for intestinal polyps in Apc1309 mice treated with PPAR ligandsa

Polyp locationPioglitazone (ppm)Bezafibrate (ppm)
0 (10)b100 (8)200 (9)0 (6)100 (6)200 (8)
Proximal small intestine9.5 ± 1.1c,d5.8 ± 1.65.5 ± 1.1e10.3 ± 1.17.7 ± 1.27.5 ± 1.5
Middle small intestine15.7 ± 1.111.4 ± 2.19.6 ± 1.8f15.0 ± 1.713.3 ± 1.211.3 ± 1.3
Distal small intestine10.9 ± 1.27.0 ± 1.3e9.0 ± 1.811.7 ± 0.511.2 ± 0.79.0 ± 1.1
Colon0.6 ± 0.20.5 ± 0.30.4 ± 0.20.7 ± 0.30.5 ± 0.30.5 ± 0.3
Total36.7 ± 2.724.6 ± 4.4e24.5 ± 4.2e37.7 ± 2.932.7 ± 1.728.3 ± 2.7e
  • a Mice were fed the basal diet or a diet containing 100 or 200 ppm of PPAR ligand for 6 weeks.

  • b Numbers in parenthesis are the numbers of animals examined.

  • c Number of polyps per mouse.

  • d Data are means ± SE.

  • e Versus the basal diet group: P < 0.05.

  • f Versus the basal diet group: P < 0.01.