Table 1

Levels of radioactivity in anesthetized gall bladder-cannulated male wild-type and Bcrp1−/− mice at 60 min. after i.v. administration of 1 mg/kg [14C]PhIP

TissueWild-typeBcrp1−/−Ratio/wt
Plasma239.5 ± 91.4574.0 ± 114.5a2.4
Brain72.2 ± 18.4199.0 ± 64.3a2.8
Testis120.6 ± 19.3313.0 ± 52.2a2.6
Spleen454.4 ± 149.3781.0 ± 349.11.7
Kidney6794.4 ± 1390.015578.6 ± 4474.4a2.3
Liver1294.8 ± 290.81928.3 ± 406.3b1.5
Small intestine2060.9 ± 340.41098.4 ± 389.4a0.5
Cecum1563.9 ± 299.01215.0 ± 425.70.8
Colon798.8 ± 147.5855.5 ± 478.31.1
Content small intestine6801.1 ± 1096.82106.1 ± 550.3a0.3
Content cecum2279.4 ± 597.8989.4 ± 275.0a0.4
Content colon2488.7 ± 889.21548.4 ± 623.00.6
  • Results are expressed as average [14C]-concentrations (ng-equivalent g−1 or ml−1) ± SD (n = 6;

  • a , P < 0.01;

  • b , P < 0.05).