Table 1

Summary of the basic competition dynamics and results from the model that includes evolution and mutation cascades

A. Summary of basic competition dynamicsa
Mutator slower than stable cellsMutator faster than stable cells
Low DNA hit rateStable cells winMutators win
High DNA hit rateMutators win if Carr > CdelbStable cells win Carr < Cdel
B. Results from modelc
Apoptosis intactApoptosis impaired
Low DNA hit rateStable cells winMutators win
High DNA hit rateMutators win if Carr > CdelStable cells win Carr < Cdel
  • a If the mutators have a lower intrinsic replication rate than the stable cells, a high DNA hit rate can select in favor of mutators. If the intrinsic replication rate of the mutators is higher than that of the stable cells, then a highDNA hit rate can select for stable cells.

  • b Carr, cost of cell cycle arrest. Cdel, cost of generating deleterious mutations.

  • c If apoptosis is intact, unstable cells have a lower intrinsic growth rate than stable cells. Hence, a high DNA hit rate can select for instability. If apoptosis is impaired, unstable cells have a higher overall intrinsic growth rate than stable cells. Thus, a high DNA hit rate can select in favor of stable cells. Carr stands for cost of cell cycle arrest, and Cdel stands for cost of generating deleterious mutations.