Table 2

Associations between ACE A-240T and I/D polymorphisms and breast cancer risk in the MEC

African AmericansJapaneseLatinasWhitesAll Groups Combined
CasesControlsOR (95% CI)aCasesControlsOR (95% CI)aCasesControlsOR (95% CI)aCasesControlsOR (95% CI)aOR (95% CI)b
A-240T genotypec
TT42781.0043561.0017781.0048701.001.00
AT1162760.75 (0.48–1.19)1591801.21 (0.76–1.94)1092671.88 (1.06–3.34)1281950.96 (0.61–1.52)1.10 (0.87–1.39)
AA902800.59 (0.37–0.94)1251551.12 (0.70–1.82)1243121.91 (1.07–3.41)1291611.14 (0.72–1.80)1.05 (0.83–1.33)
P trend0.020.820.120.440.88
AT + AA2065560.67 (0.44–1.03)2843351.17 (0.75–1.83)2335791.89 (1.09–3.30)2573561.05 (0.69–1.60)1.08 (0.86–1.34)
I/D genotypec
DD772211.0037431.00491621.00841241.001.00
ID1183101.12 (0.79–1.58)1281601.06 (0.63–1.79)1273011.38 (0.93–2.04)1291871.01 (0.70–1.47)1.16 (0.96–1.41)
II621001.76 (1.15–2.68)1191541.04 (0.62–1.75)731891.29 (0.84–1.97)79911.42 (0.92–2.18)1.30 (1.05–1.61)
P trend0.010.960.300.130.02
ID + II1804101.28 (0.93–1.77)2473141.05 (0.64–1.72)2004901.34 (0.93–1.94)2082781.14 (0.81–1.61)1.21 (1.01–1.45)
  • a Unconditional logistic regression adjusted for age, age at menarche, parity, menopausal status/HRT use, first-degree family history of breast cancer, and current alcohol consumption.

  • b Unconditional logistic regression adjusted for age, ethnicity, age at menarche, parity, menopausal status/HRT use, first-degree family history of breast cancer, and current alcohol consumption.

  • c Numbers do not add to the total number of subjects because of missing genotype data.