Table 14

Effect of topical applications of EGCG or caffeine on the induction of caspase 3-positive cells in tumors

High-risk mice (30 per group) were treated topically with acetone (100 μl) or with EGCG (6.5 μmol) or caffeine (6.2 μmol) in 100 μl acetone once daily 5 days a week for 18 weeks. Each value for the percentage of caspase 3 positive cells represents the mean ± SE. (Taken from Ref. 324 .)

TreatmentNo. of nontumor areas or tumors examinedPercentage of caspase 3 positive cellsPercentage increase
Nontumor areas
 Control3700.159 ± 0.015
 EGCG2760.123 ± 0.024
 Caffeine2710.165 ± 0.0274
Nonmalignant tumors
 Control2020.229 ± 0.017
 EGCG980.394 ± 0.031a72
 Caffeine1210.428 ± 0.033a87
Carcinomas
 Control330.196 ± 0.022
 EGCG120.305 ± 0.050b56
 Caffeine100.376 ± 0.056a92
  • a P < 0.01.

  • b P < 0.10.