Table 17

Effect of oral administration of black tea on apoptosis in established papillomas, keratoacanthomas, and squamous cell carcinomas in SKH-1 mice

Female SKH-1 mice (7–8 weeks old) were irradiated with UVB (30 mJ/cm2) twice weekly for 22 weeks, and UVB administration was stopped. Tumors were allowed to develop during the following 13 weeks, and tumor-bearing mice (17/group) were then treated with lyophilized black tea (6 mg tea solids/ml) or water as the drinking fluid for 11 weeks. The apoptosis index (TUNEL assay) was determined by evaluating the number of cells stained and the intensity of staining. Each value is the mean ± SE, and the numbers in parentheses represent percentage of increase. (Taken from Ref. 341 .)

TreatmentNumber of miceApoptosis index (mean ± SE)
Focal epidermal hyperplasiaSquamous cell papillomasKeratoacanthomasTotal nonmalignant tumorsSquamous cell carcinomasTotal tumors
Water151.37 ± 0.221.16 ± 0.320.79 ± 0.100.84 ± 0.100.77 ± 0.190.82 ± 0.09
Black tea142.15 ± 0.241.67 ± 0.441.58 ± 0.221.59 ± 0.191.50 ± 0.331.56 ± 0.17
(57)(44)(100)(89)(95)(95)