Table 3

Effect of enzyme induction in pregnant rats on the metabolism of [3H]BP in vivo

Rats pregnant for 16 days were given 20 mg of nonradioactive BP per kilogram orally once daily for 3 days. Twenty-four h after the last dose, the rats were given an oral dose of 20 mg of [3H]BP per kilogram and were killed 2 h later. The tissue concentrations of unchanged [3H]BP and its radioactive metabolites were measured. Each value represents the mean ± SE from four rats. (Taken from Ref. 24 .)

TissuePretreatment[3H]BP (ng/g)[3H]BP metabolites (ng equivalents/g)Ratio of [3H]BP metabolites to [3H]BP
FetusControl657 ± 115525 ± 490.80
BP11 ± 2742 ± 11367
PlacentaControl1994 ± 266364 ± 780.18
BP253 ± 29851 ± 1383.4
Maternal lungControl4129 ± 65293 ± 470.02
BP353 ± 361315 ± 2163.7