Table 5

Inhibitory effect of dietary curcumin on azoxymethane (AOM)-induced colon carcinogenesis in mice

CF-1 female mice were injected s.c. with AOM (10 mg/kg body weight) once weekly for 6 weeks. The mice were fed AIN 76A diet or curcumin in AIN 76A diet for 2 weeks before the first AOM administration and until the end of the experiment. The mice were killed 27 weeks after the last dose of AOM, and colon tumors were counted. Data are expressed as the mean ± SE from 34–56 mice per group. (Taken from Ref. 270 .)

Dietary inhibitorAdenomas per mouseAdenocarcinomas per mouseTumor volume per tumor (mm3)Tumor volume per mouse (mm3)
Control diet4.91 ± 0.560.72 ± 0.1511 ± 264 ± 14
0.5% Curcumin2.47 ± 0.490.31 ± 0.116 ± 119 ± 5
2.0% Curcumin2.15 ± 0.480 ± 03 ± 17 ± 2