Table 6

Effect of curcumin and all-trans retinoic acid on the differentiation of HL-60 cells as measured by nitroblue tetrazolium reduction and Mac-1 expression

HL-60 cells were treated with curcumin (CUR) and all-trans retinoic acid (RA) for 48 h, and nitroblue tetrazolium (NBT)-positive or Mac-1-positive cells were measured. The numbers in parentheses were corrected for background values from control samples. Each value represents the average of three experiments. (Taken from Ref. 291 .)

Treatment% NBT-positive cells% Mac-1-positive cells
Control3.05.6
CUR 1 μm4.6 (1.6)8.6 (3.0)
CUR 10 μm13.9 (10.9)16.5 (10.9)
RA 10 nm12.9 (9.9)16.0 (10.4)
RA 100 nm20.6 (17.6)17.4 (11.8)
RA 10 nm + CUR 10 μm79.4 (76.4)64.7 (59.1)
RA 100 nm + CUR 1 μm47.1 (44.1)34.8 (29.2)
RA 100 nm + CUR 10 μm76.3 (73.3)71.9 (66.3)