Table 7

Effect of curcumin and 1α,25-dihydroxyvitamin D3 on the differentiation of HL-60 cells as measured by nitroblue tetrazolium reduction and Mac-1 expression

HL-60 cells were treated with curcumin (CUR) and 1α,25-dihydroxyvitamin D3 (VD3) for 48 h, and nitroblue tetrazolium (NBT)-positive or Mac-1-positive cells were measured. The numbers in parentheses were corrected for background values from control samples. Each value represents the average of three experiments. (Taken from Ref. 291 .)

Treatment% NBT-positive cells% Mac-1-positive cells
Control7.85.5
CUR 1 μm12.6 (4.8)9.8 (4.3)
CUR 10 μm17.8 (10.0)16.1 (10.6)
VD3 100 nm19.1 (11.3)33.0 (27.5)
VD3 100 nm + CUR 1 μm34.2 (26.4)53.9 (48.4)
VD3 100 nm + CUR 10 μm54.0 (46.2)74.8 (69.3)