Table 1

Treatment protocols of nude mice after induction of subcutaneously growing NIH3T3-her2 tumors

Therapy group no.Mean (±SD) tumor volume at onset of ATc administration (cm3)Time between injection of NIH3T3-her2 cells and onset of ATc administration (days)No. of daily doses of 10 mg/kg ATcNo. of mice
I1.2 ± 0.216–207Controls: n = 6
Treated mice: n = 6
II3.9 ± 0.421–257Controls: n = 3
Treated mice: n = 6
III0.2 ± 0.038–1237Controls: n = 5
Treated mice: n = 7
IV0.8 ± 0.214–1640Controls: n = 5
Treated mice: n = 5
V1.9 ± 0.418–2237Treated mice: n = 4
VI14.9 ± 0.229–3130Treated mice: n = 2