Table 1

IC50 values of BMI-1026 and BMI-1042 for CDKs and the mitotic kinases Plk1 and Aurora A

CompoundIC50 (nM)
Cdk1Cdk2Cdk5Plk1Aurora APKAPKCĪ“Erk1
BMI-10268.32.30.985,0009,50025,00022,00050,000
BMI-10421.24.36.980,0004,800NDaNDND
  • a ND, not determined.