Table 1

Tissue distributions of NGR-targeted or nontargeted liposomes in SCID mice

TimeLungHeartSpleenLiverKidneyBrain
% of injected dose
NGR-3H-SL[DXR]
 2 h1.28 ± 0.630.0025.90 ± 5.0711.11 ± 4.190.38 ± 0.030.00
 12 h0.91 ± 0.110.01 ± 0.0148.42 ± 0.1223.52 ± 2.180.43 ± 0.100.00
 24 h0.86 ± 0.120.05 ± 0.0355.43 ± 3.1822.41 ± 5.920.68 ± 0.120.00
3H-SL[DXR]
 2 h0.12 ± 0.010.02 ± 0.030.32 ± 0.263.96 ± 1.840.90 ± 0.170.00
 12 h0.09 ± 0.010.03 ± 0.012.64 ± 0.1522.78 ± 0.621.10 ± 0.960.00
 24 h0.08 ± 0.010.12 ± 0.064.15 ± 0.2629.25 ± 0.991.91 ± 0.40.00