Table 1

Summary of the clinical data and mutation analysis of c-KIT codon 816 in bilateral TGCTs

The mean age of the patients at time of clinical diagnosis of the first tumor was 31.9 years (range, 15–56 years); the mean age at diagnosis was 36.6 years for seminomas and 23.8 years for nonseminomas. The mean age at diagnosis of the second tumor was 38.3 years (range, 23–59 years; mean age, 40.3 years for seminomas and 28.5 years for nonseminomas). The mean difference in age between clinical presentation of the first and second (asynchronous) tumors was 7.0 years (range, 1–19 years). These figures are in accordance with published data (see Ref. 9 for a review).

CaseTumoraAge (years)HistologybMutationcITGCNSemenPBLdRemarks
1I51SED816Y
II56SED816YD816Ye
2I32SED816YD816Ye
II35SED816YD816Y
3I26SED816VDuring projectf
II35SED816Y+VeWT
4I24NSNA
II37SED816YD816Y
5I28NSD816Y+He
II44SED816Y
6I33SED816Y
II37SED816YD816Ye
7I25NSD816YD816Y
II35NSD816Y
8I35SENAFamilialg
II54SED816Y+V+He
9I15NSD816Y+V+He
II24NSD816YD816Ye
10I37SED816Y
II47SED816Y+H
11I41SENA
II51SED816Y+Ve
12I35SED816Y+VeWT
II35SED816YWT
13I28NSD816Y
II30SED816Y
14I35SED816Y+Ve
II44SED816V
15I22NSWTD816Y+V+He
II23NSD816Y
16I31SED816Y+V+He
II34SED816VD816Y+Ve
17I56SENA
II59SED816Y
18I29SENA
II32NSD816Y+Ve
19I19NSNA
II25SEWTD816Y+Ve
20I36SED816Y+V+HeD816Y+Ve
II36SED817H
21I29NSNA
II33SED816Y+Ve
22I35SED816Y+VeD816Y+Ve
II36SED816Y+VeD816Y+Ve
  • a I, first tumor; II, second tumor.

  • b SE, seminoma; NS, nonseminoma. Tumors containing both seminomatous and nonseminomatous components (cases 4 I, 5 II, 6 I, 15 II, and 21 I) were classified as nonseminomatous.

  • c Y, tyrosine (TAC); V, valine (GTC); H, histidine (CAC); NA, not available; WT, wild type (aspartate, D; GAC).

  • d PBL, peripheral blood.

  • e Mutation was detected only after microdissection.

  • f Became bilateral during the course of the project.

  • g Familial disposition.