Table 2

Summary of c-KIT codon 816 mutation analysis in two independent series of proven bilateral TGCTs

For the results in the top portion, only the second tumor was investigated (collected in Hungary). In the bottom portion, the primary tumor with adjacent ITGCN, as well as contralateral ITGCN, were identified based on biopsy analysis (collected in Norway) see Table 1 <$REFLINK> for further explanations.

CaseAge (years)HistologyMutation
1a24SEbD816V
241NSD816Y+V
342SED816Y+V
435SED816V
525SED816V
622NSWT
740SED816Y+V
826SED816Y+V
936NSD816Y+V
1020NSD816V
1128NSD816V
1252SED816V
1333SED816Y
1441SED816V
1545SEWT
1635SED816Y+V
1723NSD816Y
1847SED816V
Contralateral biopsy with ITGCN
1ITGCND816VD816Y+V
SED816Y+V+H
2SED816Y+VD816Y
3ITGCND816Y+VD816V
4ITGCND816Y+VD816Y+V+H
SED816Y+V
5SED816Y+VD816Y+V
6SED816VD816Y+V
  • a Familial.

  • b SE, seminoma; NS, nonseminoma.