Table 3

Genes related to cholesterol metabolism that changed in the same direction in the models for acquired (LR5) and adherent (FN) drug resistance compared with the drug-sensitive cells

Shown is the fold change ± SD as well as the mean signal for each condition (n = 4). Method of statistical comparisons is described in detail in the “Materials and Methods.”

Fold changeSignalDescription
LR5FNSusaLR5FN
1.44 ± 0.511.53 ± 0.3889712401350HMG-CoA reductase
1.96 ± 1.101.53 ± 0.53100116711390Squalene epoxidase
2.39 ± 1.831.80 ± 0.94298547449Membrane-bound transcription factor protease site 1
2.14 ± 0.801.51 ± 0.4572516081078HMG-CoA synthase 1 soluble
3.69 ± 1.831.58 ± 0.583841274562Lanosterol synthase
  • a Sus, suspended cells.