Genes related to cholesterol metabolism that changed in the same direction in the models for acquired (LR5) and adherent (FN) drug resistance compared with the drug-sensitive cells
Shown is the fold change ± SD as well as the mean signal for each condition (n = 4). Method of statistical comparisons is described in detail in the “Materials and Methods.”
| Fold change | Signal | Description | |||
|---|---|---|---|---|---|
| LR5 | FN | Susa | LR5 | FN | |
| 1.44 ± 0.51 | 1.53 ± 0.38 | 897 | 1240 | 1350 | HMG-CoA reductase |
| 1.96 ± 1.10 | 1.53 ± 0.53 | 1001 | 1671 | 1390 | Squalene epoxidase |
| 2.39 ± 1.83 | 1.80 ± 0.94 | 298 | 547 | 449 | Membrane-bound transcription factor protease site 1 |
| 2.14 ± 0.80 | 1.51 ± 0.45 | 725 | 1608 | 1078 | HMG-CoA synthase 1 soluble |
| 3.69 ± 1.83 | 1.58 ± 0.58 | 384 | 1274 | 562 | Lanosterol synthase |
a Sus, suspended cells.