Table 1

Effects of aromatase inhibitors and antiestrogens treatment on cell cycle distributiona

TreatmentsbCell cycle distribution (percentage of cells)
G0-G1SG2-M
Control [AD (25 nm)]49.70 ± 2.9335.22 ± 4.0515.07 ± 2.20
Let (100 nm) + AD (25 nm)83.42 ± 1.47c10.56 ± 1.32c6.01 ± 2.79d
Anas (100 nm) + AD (25 nm)64.17 ± 2.67d30.37 ± 0.264.50 ± 1.68b
4-OHA (100 nm) + AD (25 nm)67.11 ± 1.77e24.08 ± 2.128.80 ± 3.11
4-OHTam (100 nm) + AD (25 nm)66.94 ± 9.7527.13 ± 7.095.92 ± 2.69d
Fas (100 nm) + AD (25 nm)70.24 ± 11.2027.69 ± 10.912.08 ± 1.69e
E2W (vehicle)75.97 ± 0.84c19.14 ± 0.84d4.87 ± 0.56c
  • a Results (percentage of cells distribute in cell cycle) are expressed as mean ± SE (n = 3 independent experiments).

  • b Duration of treatment is 3 days.

  • c Significantly different compared with the corresponding control value (P < 0.005).

  • d Significantly different compared with the corresponding control value (P < 0.05).

  • e Significantly different compared with the corresponding control value (P < 0.01).