Table 11

Properties of the IMP-peptides

PeptideUsed withProperties
IMP-241111In, 90Y, 177LuCan be radiolabeled to high specific activity
 (any DOTA-binding metal)Rapid clearance from blood
No hepatic or GI uptake
Low retention and gradual clearance from kidney
IMP-24399mTc/188Re/186ReCan be radiolabeled to high specific activity (99mTc-tested)
Rapid clearance from blood
Early uptake in liver with subsequent clearance through GI tract
Low retention and gradual clearance from kidney
IMP-24599mTc/188Re/186Re 111In/90Y/ 177LuCan be radiolabeled to high specific activity
Radiolabeling with 111In/90Y/177Lu may be possible
Rapid clearance from blood
No hepatic or GI uptake (99mTc-peptide)
Low retention and gradual clearance from kidney