Table 2

Biodistribution of 177Lu-IMP-241

Nude mice were injected i.v. with the peptide and necropsied at the times indicated. Values are the means ± SD (n = 5).

Tissue1 h %ID/g3 h %ID/g24 h %ID/g
Tumor0.81 ± 0.200.14 ± 0.080.03 ± 0.01
(weight, g)(0.517 ± 0.069)(0.665 ± 0.261)(0.538 ± 0.302)
Liver0.11 ± 0.010.08 ± 0.010.08 ± 0.01
Spleen0.11 ± 0.060.02 ± 0.010.05 ± 0.01
Kidney3.68 ± 0.572.52 ± 0.421.76 ± 0.53
Lung0.20 ± 0.060.05 ± 0.010.03 ± 0.01
Blood0.15 ± 0.04<0.01a<0.01a
Stomach0.09 ± 0.080.08 ± 0.120.03 ± 0.01
Sm. int0.29 ± 0.230.21 ± 0.320.03 ± 0.01
Lg. int0.05 ± 0.020.36 ± 0.450.06 ± 0.04
  • a Radioactivity concentration below threshold of detection.