Table 3

Biodistribution of 99mTc-IMP-243 and 99mTc-IMP-245

Nude mice were injected i.v. with the peptide and necropsied at the times indicated. Values are the means ± SD (n = 5).

Tissue99mTc-IMP-24399mTc-IMP-245
1 h3 h24 h30 min3 h
Tumor1.23 ± 0.380.44 ± 0.130.10 ± 0.022.11 ± 0.360.29 ± 0.11
(weight, g)(0.450 ± 0.179)(0.379 ± 0.168)(0.439 ± 0.230)(0.273 ± 0.032)(0.275 ± 0.085)
Liver3.29 ± 1.461.29 ± 0.950.15 ± 0.040.63 ± 0.100.24 ± 0.02
Spleen0.45 ± 0.090.22 ± 0.030.10 ± 0.040.46 ± 0.100.10 ± 0.01
Kidney6.57 ± 1.134.12 ± 0.861.82 ± 0.338.63 ± 2.422.38 ± 0.21
Lung1.09 ± 0.160.39 ± 0.040.10 ± 0.021.40 ± 0.320.17 ± 0.02
Blood0.99 ± 0.120.43 ± 0.110.07 ± 0.011.56 ± 0.430.19 ± 0.02
Stomach1.84 ± 0.550.68 ± 0.310.14 ± 0.060.82 ± 0.820.35 ± 0.15
Sm. int24.3 ± 4.752.53 ± 0.950.08 ± 0.021.19 ± 0.700.53 ± 0.33
Lg. int0.63 ± 0.7140.0 ± 10.40.17 ± 0.060.25 ± 0.051.13 ± 0.20