Table 3

Biodistribution of ^99mTc-IMP-243 and ^99mTc-IMP-245

Nude mice were injected i.v. with the peptide and necropsied at the times indicated. Values are the means ± SD (n = 5).

Tissue	^99mTc-IMP-243			^99mTc-IMP-245
Tissue	1 h	3 h	24 h	30 min	3 h
Tumor	1.23 ± 0.38	0.44 ± 0.13	0.10 ± 0.02	2.11 ± 0.36	0.29 ± 0.11
(weight, g)	(0.450 ± 0.179)	(0.379 ± 0.168)	(0.439 ± 0.230)	(0.273 ± 0.032)	(0.275 ± 0.085)
Liver	3.29 ± 1.46	1.29 ± 0.95	0.15 ± 0.04	0.63 ± 0.10	0.24 ± 0.02
Spleen	0.45 ± 0.09	0.22 ± 0.03	0.10 ± 0.04	0.46 ± 0.10	0.10 ± 0.01
Kidney	6.57 ± 1.13	4.12 ± 0.86	1.82 ± 0.33	8.63 ± 2.42	2.38 ± 0.21
Lung	1.09 ± 0.16	0.39 ± 0.04	0.10 ± 0.02	1.40 ± 0.32	0.17 ± 0.02
Blood	0.99 ± 0.12	0.43 ± 0.11	0.07 ± 0.01	1.56 ± 0.43	0.19 ± 0.02
Stomach	1.84 ± 0.55	0.68 ± 0.31	0.14 ± 0.06	0.82 ± 0.82	0.35 ± 0.15
Sm. int	24.3 ± 4.75	2.53 ± 0.95	0.08 ± 0.02	1.19 ± 0.70	0.53 ± 0.33
Lg. int	0.63 ± 0.71	40.0 ± 10.4	0.17 ± 0.06	0.25 ± 0.05	1.13 ± 0.20