Table 4

Pretargeting of 99mTc-IMP-243 using hMN-14 × m679 F(ab′)2 bsMAb

Tissue3 h after peptide injection (n = 5)24 h after peptide injection (n = 4)
125I-bsMAb %ID/g99mTc-IMP-243125I-bsMAb %ID/g99mTc-IMP-243
%ID/gT:NT%ID/gT:NT
Tumor4.78 ± 1.1112.25 ± 3.322.24 ± 0.537.36 ± 3.19
(weight, g)(0.547 ± 0.265)(0.390 ± 0.265)
Liver1.17 ± 0.192.00 ± 0.356.2 ± 1.50.27 ± 0.080.51 ± 0.1314.4 ± 4.4
Spleen2.24 ± 0.571.55 ± 0.438.4 ± 2.90.60 ± 0.230.48 ± 0.1515.9 ± 6.3
Kidney0.81 ± 0.214.52 ± 0.792.7 ± 0.50.20 ± 0.052.08 ± 0.383.5 ± 1.3
Lungs1.02 ± 0.292.41 ± 0.605.3 ± 1.70.24 ± 0.040.53 ± 0.1214.1 ± 4.9
Blood1.48 ± 0.355.31 ± 1.322.4 ± 0.60.41 ± 0.081.08 ± 0.296.9 ± 2.3
Stomach7.61 ± 3.331.51 ± 0.649.5 ± 4.60.57 ± 0.260.27 ± 0.1427.8 ± 1.5
Sm. int0.51 ± 0.155.44 ± 2.422.4 ± 0.70.10 ± 0.030.37 ± 0.2122.2 ± 8.0
Lg. int1.22 ± 0.1024.79 ± 2.820.5 ± 0.20.09 ± 0.040.80 ± 0.4810.4 ± 3.3