Table 7

Pretargeting of 111In-IMP-241 using hMN-14 × m679 F(ab′)2 bsMAb (24-h bsMAb clearance)

TimeTissue125I-bsMAb111In-241
%ID/g%ID/gT:NT
3 h after 111In-IMP-241 injection (n = 5)Tumor (0.254 ± 147 g)2.92 ± 0.4111.3 ± 2.2
Liver0.44 ± 0.240.53 ± 0.1422.2 ± 6.3
Spleen0.94 ± 0.410.42 ± 0.1227.8 ± 5.9
Kidney0.44 ± 0.174.61 ± 0.712.5 ± 0.5
Lungs0.49 ± 0.240.83 ± 0.2314.1 ± 2.8
Blood0.79 ± 0.241.44 ± 0.338.1 ± 2.1
Stomach3.18 ± 2.270.11 ± 0.02102.9 ± 15.2
Sm. intestine0.27 ± 0.150.23 ± 0.0853.4 ± 14.4
Lg. intestine0.35 ± 0.180.31 ± 0.0737.4 ± 9.2
24 h after 111In-IMP-241 injection (n = 4)Tumor (0.203 ± 0.090 g)1.80 ± 0.346.87 ± 0.84
Liver0.10 ± 0.030.31 ± 0.0522.3 ± 2.5
Spleen0.35 ± 0.200.40 ± 0.1318.5 ± 5.6
Kidney0.11 ± 0.022.60 ± 0.432.7 ± 0.5
Lungs0.13 ± 0.020.29 ± 0.0524.0 ± 5.7
Blood0.23 ± 0.030.43 ± 0.1016.4 ± 3.3
Stomach0.21 ± 0.060.06 ± 0.01116.9 ± 10.2
Sm. intestine0.05 ± 0.010.10 ± 0.0267.3 ± 9.6
Lg. intestine0.04 ± 0.010.11 ± 0.0366.0 ± 12.2
48 h after 111In-IMP-241 injection (n = 5)Tumor (0.206 ± 0.073 g)1.32 ± 0.155.47 ± 1.03
Liver0.06 ± 0.010.27 ± 0.0520.4 ± 4.1
Spleen0.24 ± 0.140.40 ± 0.0513.6 ± 2.0
Kidney0.07 ± 0.011.17 ± 0.214.7 ± 0.46
Lungs0.07 ± 0.020.19 ± 0.0428.9 ± 6.5
Blood0.11 ± 0.020.17 ± 0.0332.0 ± 7.2
Stomach0.09 ± 0.030.04 ± 0.02163.2 ± 53.9
Sm. intestine0.03 ± 0.010.07 ± 0.0276.8 ± 16.2
Lg. intestine0.02 ± 0.010.07 ± 0.0283.0 ± 16.8