Pretargeting of 111In-IMP-241 using mMu-9 × m679 F(ab′)2 bsMAb (48-h bsMAb clearance)
| Time | Tissue | 125I-bsMAb | 111In-241 | |
|---|---|---|---|---|
| %ID/g | %ID/g | T:NT | ||
| 3 h after 111In-IMP-241 injection | Tumor (0.164 ± 0.064 g) | 13.1 ± 4.36 | 17.8 ± 1.4 | — |
| Liver | 0.19 ± 0.03 | 0.56 ± 0.08 | 32.0 ± 3.0 | |
| Spleen | 0.28 ± 0.12 | 0.46 ± 0.13 | 41.2 ± 10.6 | |
| Kidney | 0.32 ± 0.04 | 3.63 ± 0.34 | 4.9 ± 0.5 | |
| Lungs | 0.31 ± 0.05 | 0.92 ± 0.21 | 20.0 ± 2.9 | |
| Blood | 0.55 ± 0.10 | 1.93 ± 0.63 | 9.7 ± 2.0 | |
| Stomach | 0.75 ± 0.21 | 0.15 ± 0.07 | 130.2 ± 41.0 | |
| Sm. intestine | 0.11 ± 0.02 | 0.28 ± 0.12 | 70.5 ± 20.4 | |
| Lg. intestine | 0.10 ± 0.02 | 0.20 ± 0.07 | 98.1 ± 27.9 | |
| 24 h after 111In-IMP-241 injection | Tumor (0.214 ± 0.040 g) | 12.4 ± 4.2 | 17.5 ± 4.1 | — |
| Liver | 0.10 ± 0.02 | 0.44 ± 0.10 | 39.8 ± 6.5 | |
| Spleen | 0.15 ± 0.05 | 0.35 ± 0.08 | 50.3 ± 7.1 | |
| Kidney | 0.15 ± 0.03 | 2.28 ± 0.35 | 7.7 ± 1.9 | |
| Lungs | 0.12 ± 0.02 | 0.31 ± 0.05 | 56.0 ± 6.0 | |
| Blood | 0.22 ± 0.05 | 0.38 ± 0.12 | 47.6 ± 11.2 | |
| Stomach | 0.17 ± 0.04 | 0.05 ± 0.01 | 377.6 ± 101.8 | |
| Sm. intestine | 0.05 ± 0.01 | 0.09 ± 0.02 | 195.7 ± 49.7 | |
| Lg. intestine | 0.03 ± 0.01 | 0.08 ± 0.02 | 235.8 ± 58.4 | |
| 48 h after 111In-IMP-241 injection | Tumor (0.213 ± 0.064 g) | 11.2 ± 5.5 | 12.7 ± 4.8 | — |
| Liver | 0.06 ± 0.01 | 0.29 ± 0.06 | 44.6 ± 16.2 | |
| Spleen | 0.06 ± 0.01 | 0.25 ± 0.05 | 50.6 ± 14.1 | |
| Kidney | 0.06 ± 0.01 | 0.99 ± 0.35 | 12.9 ± 2.6 | |
| Lungs | 0.05 ± 0.01 | 0.14 ± 0.01 | 90.8 ± 32.3 | |
| Blood | 0.07 ± 0.01 | 0.10 ± 0.02 | 127.8 ± 41.7 | |
| Stomach | 0.10 ± 0.04 | 0.04 ± 0.01 | 338 ± 148.5 | |
| Sm. intestine | 0.02 ± 0.00 | 0.07 ± 0.01 | 189.9 ± 71.1 | |
| Lg. intestine | 0.02 ± 0.01 | 0.07 ± 0.02 | 168.0 ± 40.9 | |