Table 8

Pretargeting of 111In-IMP-241 using mMu-9 × m679 F(ab′)2 bsMAb (48-h bsMAb clearance)

TimeTissue125I-bsMAb111In-241
%ID/g%ID/gT:NT
3 h after 111In-IMP-241 injectionTumor (0.164 ± 0.064 g)13.1 ± 4.3617.8 ± 1.4
Liver0.19 ± 0.030.56 ± 0.0832.0 ± 3.0
Spleen0.28 ± 0.120.46 ± 0.1341.2 ± 10.6
Kidney0.32 ± 0.043.63 ± 0.344.9 ± 0.5
Lungs0.31 ± 0.050.92 ± 0.2120.0 ± 2.9
Blood0.55 ± 0.101.93 ± 0.639.7 ± 2.0
Stomach0.75 ± 0.210.15 ± 0.07130.2 ± 41.0
Sm. intestine0.11 ± 0.020.28 ± 0.1270.5 ± 20.4
Lg. intestine0.10 ± 0.020.20 ± 0.0798.1 ± 27.9
24 h after 111In-IMP-241 injectionTumor (0.214 ± 0.040 g)12.4 ± 4.217.5 ± 4.1
Liver0.10 ± 0.020.44 ± 0.1039.8 ± 6.5
Spleen0.15 ± 0.050.35 ± 0.0850.3 ± 7.1
Kidney0.15 ± 0.032.28 ± 0.357.7 ± 1.9
Lungs0.12 ± 0.020.31 ± 0.0556.0 ± 6.0
Blood0.22 ± 0.050.38 ± 0.1247.6 ± 11.2
Stomach0.17 ± 0.040.05 ± 0.01377.6 ± 101.8
Sm. intestine0.05 ± 0.010.09 ± 0.02195.7 ± 49.7
Lg. intestine0.03 ± 0.010.08 ± 0.02235.8 ± 58.4
48 h after 111In-IMP-241 injectionTumor (0.213 ± 0.064 g)11.2 ± 5.512.7 ± 4.8
Liver0.06 ± 0.010.29 ± 0.0644.6 ± 16.2
Spleen0.06 ± 0.010.25 ± 0.0550.6 ± 14.1
Kidney0.06 ± 0.010.99 ± 0.3512.9 ± 2.6
Lungs0.05 ± 0.010.14 ± 0.0190.8 ± 32.3
Blood0.07 ± 0.010.10 ± 0.02127.8 ± 41.7
Stomach0.10 ± 0.040.04 ± 0.01338 ± 148.5
Sm. intestine0.02 ± 0.000.07 ± 0.01189.9 ± 71.1
Lg. intestine0.02 ± 0.010.07 ± 0.02168.0 ± 40.9