Table 1

The antitumor activity of ARC-111, TPT, and CPT-11 against SKNEP anaplastic Wilms’ tumor xenografts

TreatmentAverage week tumor achieved 4× initial volume ± SDPaNumber PRsbNumber CRsNumber MCRs
Control2.0 ± 0.0000
CPT-11 (1.25 mg/kg)4.7 ± 1.60.005110
Topotecan (2 mg/kg)6.0 ± 0.00.01310
Control2.1 ± 1.1000
ARC-111 (2 mg/kg)>120.00001010
ARC-111 (1 mg/kg)4.8 ± 2.00.017320
  • a Level of significance relative to controls.

  • b PR, partial response (≥50% volume regression); CR, complete response; MCR, maintained CR at week 12.