Table 2

Frequencies of inferred haplotypes in cases and controlsa

HaplotypesAllele Frequency
C26304T (Arg194Trp)C26602TG28152A (Arg399Gln)G36189A (Gln632Gln)Cases (n, %) n = 1896Controls (n, %) n = 2587P
0000222 (11.7)299 (11.6)0.91b
0001766 (40.4)1063 (41.1)0.66b
0010689 (36.3)913 (35.3)0.49b
0100106 (5.6)120 (4.6)0.17b
1000100 (5.3)171 (6.6)0.07b
00118 (0.4)17 (0.7)0.40b
10015 (0.3)4 (0.2)0.51c
  • a Haplotype frequencies from our observed genotypes were estimated by the Partition-Ligation EM algorithm. “0” stands for more common allele; “1” stands for less common allele. P2, df = 6) = 0.41. Three additional rare haplotypes were predicted in five alleles in controls only; one haplotype was predicted in one allele, two in two.

  • b P is based on χ2 test.

  • c P is based on Fisher’s exact test.