Table 1

Summary of TP53 mutation analysis and EGFR FISH analysis

CaseTP53 mutationEGFR amplification patternAverage EGFR numberAverage control numberMode of chromosome 7
12.352.312
23.072.923
33.233.183
4+++a>1003.343
5+++, periphery>1003.573
6+++, periphery>1002.562
7+++, periphery>1002.793
8+++, periphery>1003.053
9+3.073.003
10+2.111.992
11++, isolated3.223.173
12++, isolated3.883.844
13++, isolated1.951.992
14++, isolated4.214.124
  • a +++ = numerous cells with amplification; periphery = amplified cells more numerous at probable edge of lesion; +, isolated = rare, scattered cells with amplification.