Table 1

Frequencies of loss and gain for each chromosome arma

Chromosome armGenomic lossGenomic gain
BRCA1 (%)BRCA2 (%)Non-1/2 (%)Sporadic (%)Total (%)Critical regionsBRCA1 (%)BRCA2 (%)Non-1/2 (%)Sporadic (%)Total (%)Critical regions
1p1717182519 39 61 53 61 51 pter-p32
1q15135710 43 61 56 50 52 cen-q22; q31-qter
2p0504226 43 34 32 33 pter-p14
2q282223 32 26q21-q32 29 26162123q33-qter
3p 39 43 39 36 39 pter-p22; p13-cen913162916
3q11991811 52 56 43 43 48 q21-qter
4p 37 34 41 39 38 p14-cen917181113
4q 74 91 70 75 76 cen-q31.375345
5p1117141113 44 39 32 25 35 pter-p14
5q 78 74 73 54 71 q13-q221731121417q32-qter
6p957149 52 53 45 36 47 pter-p22
6q 80 83 70 68 75 q21-q2329745
7p26 39 232527pter-p15119111411
7q797118 52 48 52 43 50 q21-qter
8p 37 39 43 25 37 pter-p2116071410
8q713546 83 78 64 64 72 q23-qter
9p 41 43 30 43 38 pter-p2124991114
9q26 43 7 50 28q21-q2226 31 45 25 33 q31-qter
10p95505 31 922 32 25pter-p13
10q152223181917 35 182522q24-qter
11p24 31 271424pter-p14906117
11q229232521 45 53 32 18 37 cen-q13; q23-qter
12p13137111128 34 27 36 30 pter-p12
12q 43 22 34 21 33 q21-q23 31 34 233630q24.1-qter
13q 59 87 55 64 63 cen-q14; q21-q2299706
14q 30 48 27 39 34 cen-q13242612 32 22q24-qter
15q 30 43 39 36 36 cen-q15; q21-q23 33 43 142928q24-qter
16p4011462122141418
16q 30 31 43 39 36 cen-q2190746
17p 39 34 32 11 30 17p25444
17q 41 17271828cen-q21 31 34 262929q22-qter
18p9071495 30 162116
18q 59 61 52 46 55 q21-qter917121112
19p2027329 31 39 46 36 19p
19q40001 43 53 50 54 49 19q
20p00501 39 39 28 39 36 20p
20q00000 66 78 61 68 67 20q
21q 28 35 18212521q 31 39 23292921q
22q2422251422171719 43 2322q
Xp 37 43 36 57 42 Xp115346
Xq 43 58 57 54 52 q21-qter2217141417
  • a The frequencies of loss or gain were established from the number of chromosome arms that had either type of genetic alteration. Frequencies ≥ 30% are highlighted in bold. Critical regions of loss and gain were determined only for alterations with a frequency of ≥ 30% for one or more of the four tumor groups.