Table 3

Reconstructed ATM haplotypes

HaplotypeSequenceaControlAll BCbOR (95% CI)non-RS-BCRS-BCOR (95% CI)
AH1TTTCCCGTGAC2932001.00137631.00
AH2TTCCCCGTGAG180175 1.42 (1.08–1.88) 13639 0.62 (0.39–0.99)
AH3TTTCCCGTAAC62501.18 (0.78–1.79)33171.12 (0.58–2.16)
AH4TTCCCTGTGAG21201.40 (0.74–2.64)1460.93 (0.34–2.54)
AH5TTTCCCGCAAC16171.56 (0.77–3.15)1340.67 (0.21–2.13)
AH6TCTGCCGTGAC15100.97 (0.43–2.22)910.24 (0.03–1.95)
AH7CTTCCCGTGAC960.97 (0.34–2.79)60NC
AH8TTTGCCGTGAC881.47 (0.54–3.97)710.31 (0.04–2.58)
AH9TTCCCCCTGAG520.59 (0.11–3.05)112.18 (0.13–35.35)
AH10TTCCTCGTGAG551.47 (0.42–5.13)321.45 (0.24–8.90)
AH11TTTCCCGTGAG431.10 (0.24–4.96)211.09 (0.10–12.22)
AH12TTTCCCGTGTC362.93 (0.72–11.86)510.43 (0.05–3.80)
OtherVariable362.93 (0.72–11.86)244.35 (0.78–24.38)
Total624508368140
  • a The nucleotide positions and bp changes defining the haplotypes are T2119C, T2572C, IVS22-77 T>C, C3161G, C4258T, C4578T, IVS38-15 G>C, IVS38-8 T>C, G5557A, A5558T, and IVS48+238 C>G. Base changes from the wild-type sequence are indicated in bold and underlined.

  • b BC, breast cancer; OR, odds ratio; CI, confidence interval; RS, radiation sensitive; NC, not calculated.