Table 2

The relationship of MTHFR genotypes with total plasma homocysteine levels depending on folate intakea

Folate intakeNHomocysteinea according to MTHFR genotypeP
Ala/AlaAla/ValVal/Val
All subjects80414.8 (0.4)15.5 (0.4)21.6 (0.9)0.0001
Folate intake tertiles
 <169.8 μg/day26815.6 (0.7)17.2 (0.7)25.1 (1.4)0.0001
 169.8–214.8 μg/day26715.0 (0.7)14.6 (0.7)24.3 (1.8)0.0001
 >214.8 μg/day26913.6 (0.7)14.7 (0.7)14.7 (1.6)0.38
Interaction0.0006
  • a Values in parentheses for variables are SEs. Folate intake is estimated as described in “Materials and Methods.”

  • b In μmol/liter.