Table 1

Univariate analysis of 30-year disease-related survival

MarkernPRelative risk95% confidence interval
HER2 manual score0.0071
 01531.00
 1+500.93831.020.68–1.52
 2+130.97631.010.49–2.08
 3+280.00072.251.41–3.58
HER2 AQUA score0.0009
 Normal460.00911.711.14–2.56
 Intermediate1881.00
 High300.00132.181.35–3.51
HER2 amplification (FISH)220.81211.070.60–1.90
Nodal involvement0.0279
 1–3681.00
 4–9540.67081.080.75–1.55
 ≥101410.00861.621.13–2.33
Tumor size (cm)0.0007
 <2801.00
 2–5530.12551.330.92–1.93
 >51020.00012.091.43–3.07
Nuclear grade
 High950.00401.551.15–2.08
Estrogen receptor
 Negative1040.02621.411.041–1.906