HIN-1 and BRCA1 promoter methylation in various breast cancer types
HIN-1 and BRCA1 promoter methylation was evaluated by MSP. Both partially and completely methylated samples are listed together as methylated. Subtypes of unselected cancers do not sum to the total because complete immunohistochemical data were not available for all tumors. BRCA1-like tumors were defined as ER- and HER2-negative high-grade tumors.
| Breast cancer type | HIN-1 | BRCA1 | ||||
|---|---|---|---|---|---|---|
| Sample size | Unmethylated | Methylated | Sample size | Unmethylated | Methylated | |
| No. (%) | No. (%) | No. (%) | No. (%) | |||
| Sporadic cancers | 114 | 37 (32) | 77 (68) | 96 | 65 (68) | 31 (32) |
| ER+HER2+ | 25 | 6 (24) | 19 (76) | 25 | 15 (60) | 10 (40) |
| ER+HER2− | 26 | 3 (12) | 23 (88) | 24 | 18 (75) | 6 (25) |
| ER−HER2+ | 29 | 12 (41) | 17 (59) | 29 | 18 (62) | 11 (38) |
| BRCA1-like | 14 | 9 (64) | 5 (36) | 15 | 14 (93) | 1 (7) |
| BRCA1-associated | 18 | 16 (89) | 2 (11) | 18 | 16 (89) | 2 (11) |
| Familial (non-BRCA1) | 5 | 2 (40) | 3 (60) | 6 | 6 (100) | 0 (0) |