Table 1

Summary of growth characteristics of MXT and EMT-6 tumors during and after three courses of chemotherapya

TumorDrugDoubling time between and after courses of chemotherapyTime to grow to 1 cm3 (days)
d0–d7d7–d14d14–d21d21–d28
MXTControl2.34.3/b/18
5FU4.410.28.84.829.5
CY6.96.213.94.936
EMT-6Control5.24.7//20.5
5FU9.610.66.1/29.5
CY14.28.813.1/>32c
  • a Chemotherapy 100 mg/kg CY or 50 mg/kg 5FU was given i.p. once weekly on days 0, 7, and 14.

  • b Not available.

  • c When experiments were ceased on day 32 after tumor inoculation, the average tumor volume of CY-treated mice was <1 cm3.