Table 2

Proportional areas occupied by BrdUrd-labeled tumor cell nuclei after three weekly courses of chemotherapy^a

Groups	No. of hot spots	Proportional areas of positive cells (%, means ± SE)
Groups	No. of hot spots	MXT tumor	EMT-6 tumor
Ctrl d7	49	10.7 ± 0.1	3.9 ± 0.9
CY d7	44	11.9 ± 0.7	5.0 ± 0.3^b
CY d14	34	14.7 ± 2.9^b	13.3 ± 2.8^b
CY d21	44	14.9 ± 2.0^b	10.9 ± 3.9^b
CY d28	44	20.7 ± 0.4^b	N/A^c
Ctrl d7	44	9.0 ± 0.9	3.9 ± 0.9
5FU d7	34	11.0 ± 0.3^b	11.0 ± 0.3^b
5FU d14	34	9.1 ± 2.2	8.1 ± 3.1^b
5FU d21	44	15.8 ± 0.5^b	14.0 ± 0.9^b
5FU d28	44	14.2 ± 3.6^b	N/A^c

^a Data were based on the hot spot method (note that this estimates labeled nuclei per unit area and not the proportion of labeled nuclei as in the random field method).
^b P < 0.05 compared with control tumors.
^c Not available; because skin ulcerations were very common in EMT6 tumors after 21 days of treatment, the animals had to be killed.