Table 2

Proportional areas occupied by BrdUrd-labeled tumor cell nuclei after three weekly courses of chemotherapya

GroupsNo. of hot spotsProportional areas of positive cells (%, means ± SE)
MXT tumorEMT-6 tumor
Ctrl d74910.7 ± 0.13.9 ± 0.9
CY d74411.9 ± 0.75.0 ± 0.3b
CY d143414.7 ± 2.9b13.3 ± 2.8b
CY d214414.9 ± 2.0b10.9 ± 3.9b
CY d284420.7 ± 0.4bN/Ac
Ctrl d7449.0 ± 0.93.9 ± 0.9
5FU d73411.0 ± 0.3b11.0 ± 0.3b
5FU d14349.1 ± 2.28.1 ± 3.1b
5FU d214415.8 ± 0.5b14.0 ± 0.9b
5FU d284414.2 ± 3.6bN/Ac
  • a Data were based on the hot spot method (note that this estimates labeled nuclei per unit area and not the proportion of labeled nuclei as in the random field method).

  • b P < 0.05 compared with control tumors.

  • c Not available; because skin ulcerations were very common in EMT6 tumors after 21 days of treatment, the animals had to be killed.