Table 1

17-AAG enhanced the activity of Taxol

Mean change in initial tumor volume at day 35 (1 week after completing treatment) and the percentage of complete responses in each treatment arm.

Mean % volume change (day 35)% CRaPvs. TaxolPvs. 17-AAG 50 mg/kg 3x/wk
Vehicle controls466-
17-AAG 50 mg/kg qwk448-
17-AAG 150 mg/kg qwk15210%
17-AAG 50 3×/wk−520%
Taxol236.7%
Taxol + 17-AAG 50 mg/kg qwk−8320%0.02< 0.01
Taxol + 17-AAG 150 mg/kg qwk−8740%< 0.01< 0.01
Taxol + 17-AAG 50 mg/kg 3x/wk−8640%< 0.01< 0.01
  • %CR, % complete responses. n = 15 for the vehicle and Taxol-treated groups, n = 10 for the 17-AAG and combination groups.